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Kabita Sharma

Kabita Sharma is a Ph.D. student in the Department of Chemistry at the University of North Texas, USA. Her research focuses on understanding protein degradation mediated by PROTAC (Proteolysis-Targeting Chimera) molecules and on exploring their potential for targeted protein degradation to treat diseases such as cancer. Through this work, she aims to advance drug discovery by targeting previously inaccessible or undruggable sites where PROTAC molecules can operate effectively. Additionally, she is analyzing how the buried surface area of proteins affects their binding and unbinding affinities. Using computational tools, she explores the challenges of removing one infected protein from another during treatment. Driven by a passion for solving complex scientific challenges, Kabita uses her knowledge in chemistry, chemical biology, and computational tools to advance her research. Beyond her academic pursuits, she aspires to inspire others toward science and its wonders through writing and sharing her knowledge.

HPLC: Principle, Types, Parts, Applications, Advantages, Disadvantages

January 20, 2023January 11, 2023 by Kabita Sharma
High performance liquid chromatography (HPLC) 

High performance liquid chromatography (HPLC)  technique involves the separation of analytes dissolved in the mobile phase using a particular interaction with a stationary phase. In general, it is a greatly enhanced form of column chromatography. A solvent is forced through … Read more

Affinity chromatography: Principle, Procedure, Applications, Advantage

January 12, 2023January 10, 2023 by Kabita Sharma
Affinity chromatography

Affinity chromatography is a liquid chromatography technique that employs biospecific interactions to separate compounds. The molecule that needs to be purified is selectively and irreversibly adsorbed to a certain ligand. History of Affinity chromatography Immunochemists were the ones who created … Read more

Darzens reaction: Definition, Mechanism, Stereochemistry, Synthetic Applications

January 11, 2023January 9, 2023 by Kabita Sharma
Darzens reaction

Darzens reaction is a condensation reaction that involves the reaction of ketone or aldehyde with an α-haloester in the presence of a base to form an α,β-epoxy ester i.e., glycidic ester. It is commonly known as Darzens condensation or glycidic … Read more

Haloform Reaction: Definition , Mechanism, Synthetic Applications, Limitations

January 9, 2023January 8, 2023 by Kabita Sharma
 Haloform reaction

 Haloform reaction involves an exhaustive halogenation of a methyl ketone (RCOCH3) in the presence of a base to give a haloform (CHX3).  Where R can be either a hydrogen atom, an alkyl, or an aryl group, and X is a … Read more

Favorskii rearrangement: Definition , Mechanism, Synthetic Applications

January 11, 2023January 4, 2023 by Kabita Sharma
Favorskii rearrangement

Favorskii rearrangement involves the conversion of cyclopropanones or α -halo ketones to carboxylic acids or their derivatives in presence of the base. Acidic “‘ α -hydrogens” must be present in the halo ketones. This reaction is named after the Russian … Read more

Finkelstein reaction: Definition , Mechanism, Synthetic Applications, Limitations

January 9, 2023January 3, 2023 by Kabita Sharma
Finkelstein Reaction

 Finkelstein reaction is an organic process in which an alkyl halide reacts with a metal halide salt to form another alkyl halide. This reaction’s name is given after the German chemist Hans Finkelstein. It is a nucleophilic bimolecular substitution reaction in which … Read more

Grignard reaction: Definition , Mechanism, Synthetic Applications, Limitations

January 9, 2023December 31, 2022 by Kabita Sharma
Grignard reaction

Grignard reaction describes the addition of alkyl magnesium halides to the carbonyl group of aldehyde or ketone. This reaction is one of the most significant process for the formation of carbon-carbon bonds. In this reaction process alkyl, vinyl, or aryl … Read more

Balz–Schiemann Reaction: Definition , Mechanism, Synthetic Applications

January 11, 2023December 31, 2022 by Kabita Sharma
Balz–Schiemann reaction

Balz–Schiemann reaction involves the transformation of a primary aromatic amine into an aryl fluoride via a diazonium tetrafluoroborate intermediate. The process is comparable to the Sandmeyer reaction, which also produces aryl halides from diazonium salts. In this process, arylamines are … Read more

Etard Reaction: Definition, Mechanism, Synthetic Applications, Limitations

December 30, 2022December 29, 2022 by Kabita Sharma
Etard reaction

Etard reaction is a chemical reaction that involves the direct oxidation of an aromatic or heterocyclic bound methyl group to an aldehyde using chromyl chloride. It is named after French Scientist Alexandre Leon Etard. In this reaction, chromyl chloride serves … Read more

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