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Organic Chemistry

Organic chemistry is a branch of chemistry that examines the structure, characteristics, and interactions of organic molecules that have covalent bonds with carbon.

  • Organic chemistry is a large field due to a critical feature of the element carbon known as carbon catenation. Carbon has a remarkable ability to make extremely stable bonds with other carbon atoms, allowing it to construct stable molecules with relatively complex structures. Catenation is an element’s ability to create bonds with atoms of the same type. As a result, this characteristic of carbon can be used to explain the complexity of organic chemistry.
  • More than a million carbon compounds are known due to their ability in creating covalent bonds. Many are hydrocarbons, which are made up of simply carbon and hydrogen. The majority of hydrocarbons are derived from petroleum.
  • Jöns Jakob Berzelius, a Swedish scientist, used the term “organic” in 1807 to describe chemicals produced by living organisms. Organic molecules were once thought to be impossible to manufacture artificially because they carried a mystical essence of life known as “vital force.”
  • Friedrich Wöhler synthesized the organic chemical urea from inorganic starting materials in 1828, demonstrating that a compound synthesized by living cells could be synthesized in the laboratory without the use of biological starting materials, thus contradicting a basic tenet of vitalism.
  • The synthesis of urea represented the beginning of a new era in organic chemistry, not only redefining the term organic but also rerouting organic chemistry into a wholly new scientific subject.
  • The modern definition of organic is carbon-containing substances, which is now the scientific manner of characterizing the term. However, organic compounds have remained important to every known lifeform over the years, as an abundance of organic molecules comprise all living species.
  • Organic compounds are the foundation of all life on Earth and account for the vast majority of known substances. The variety of organic compounds is structurally complex, and their range of uses is extensive because of the bonding patterns of carbon, which has a valence of four and formal single, double, and triple bonds as well as structures with delocalized electrons.
  • Organic chemistry studies carbon-containing molecules’ structure, characteristics, content, reactions, and production. Most organic molecules comprise carbon and hydrogen but can also contain nitrogen, oxygen, halogens, phosphorus, silicon, and sulfur.
  • Organic chemistry is significant because organic compounds are the majority of the vital biological molecules in living systems. Almost all common polymers are made from organic molecules.
  • They are the foundation or ingredients of many commercial items, including pharmaceuticals, petrochemicals, and agrichemicals, as well as products made from them, such as lubricants, solvents, plastics, fuels, and explosives.
  • Organometallic chemistry, which studies carbon-based molecules including metals, and bioorganic chemistry, which integrates organic chemistry with biochemistry, are two new disciplines of organic chemistry.
  • Organic chemistry methods are applied in pharmaceutical chemistry, natural product chemistry, and materials science. Organic chemists in industry work in both discovery chemistry (creating new chemicals) and process optimization (developing better synthetic methods for large-scale production).

HPLC: Principle, Types, Parts, Applications, Advantages, Disadvantages

January 20, 2023January 11, 2023 by Kabita Sharma
High performance liquid chromatography (HPLC) 

High performance liquid chromatography (HPLC)  technique involves the separation of analytes dissolved in the mobile phase using a particular interaction with a stationary phase. In general, it is a greatly enhanced form of column chromatography. A solvent is forced through … Read more

Affinity chromatography: Principle, Procedure, Applications, Advantage

January 12, 2023January 10, 2023 by Kabita Sharma
Affinity chromatography

Affinity chromatography is a liquid chromatography technique that employs biospecific interactions to separate compounds. The molecule that needs to be purified is selectively and irreversibly adsorbed to a certain ligand. History of Affinity chromatography Immunochemists were the ones who created … Read more

Darzens reaction: Definition, Mechanism, Stereochemistry, Synthetic Applications

January 11, 2023January 9, 2023 by Kabita Sharma
Darzens reaction

Darzens reaction is a condensation reaction that involves the reaction of ketone or aldehyde with an α-haloester in the presence of a base to form an α,β-epoxy ester i.e., glycidic ester. It is commonly known as Darzens condensation or glycidic … Read more

Haloform Reaction: Definition , Mechanism, Synthetic Applications, Limitations

January 9, 2023January 8, 2023 by Kabita Sharma
 Haloform reaction

 Haloform reaction involves an exhaustive halogenation of a methyl ketone (RCOCH3) in the presence of a base to give a haloform (CHX3).  Where R can be either a hydrogen atom, an alkyl, or an aryl group, and X is a … Read more

Cope Rearrangement Reaction: Reaction Mechanism, Stereochemistry, Application

January 6, 2023 by Jyoti Bashyal
Cope Rearrangement Reaction

Cope rearrangement of 1,5-dienes is one of the most fundamental C-C bonds-formation reactions available to synthetic chemists today. It is exceptional in the formation of highly stereospecific and predictable C-C  σ -bonds between non functionalized carbon centers. Elizabeth Hardy and Arthur … Read more

Favorskii rearrangement: Definition , Mechanism, Synthetic Applications

January 11, 2023January 4, 2023 by Kabita Sharma
Favorskii rearrangement

Favorskii rearrangement involves the conversion of cyclopropanones or α -halo ketones to carboxylic acids or their derivatives in presence of the base. Acidic “‘ α -hydrogens” must be present in the halo ketones. This reaction is named after the Russian … Read more

Finkelstein reaction: Definition , Mechanism, Synthetic Applications, Limitations

January 9, 2023January 3, 2023 by Kabita Sharma
Finkelstein Reaction

 Finkelstein reaction is an organic process in which an alkyl halide reacts with a metal halide salt to form another alkyl halide. This reaction’s name is given after the German chemist Hans Finkelstein. It is a nucleophilic bimolecular substitution reaction in which … Read more

Grignard reaction: Definition , Mechanism, Synthetic Applications, Limitations

January 9, 2023December 31, 2022 by Kabita Sharma
Grignard reaction

Grignard reaction describes the addition of alkyl magnesium halides to the carbonyl group of aldehyde or ketone. This reaction is one of the most significant process for the formation of carbon-carbon bonds. In this reaction process alkyl, vinyl, or aryl … Read more

Aldol Condensation: Definition, Reaction Mechanism, and Applications

December 31, 2022 by Jyoti Bashyal
Aldol Condensation Reaction Mechanism

Aldol condensations are significant in the synthesis of organic compounds because they offer a reliable method for forming carbon-carbon bonds. One of the crucial reactions involving carbonyl compounds (i.e. aldehydes and ketones) is the aldol condensation reaction. The Robinson annulation … Read more

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